Not known Factual Statements About akorn promethazine codeine

Neuroleptic malignant syndrome (NMS) which may result in Dying. Tell you Health care service provider instantly For those who have any of the next signs and symptoms of NMS: higher fever

Breathing issues (respiratory melancholy) that may result in Dying and opioid withdrawal can transpire if you start taking or prevent using other medicines while taking Promethazine Hydrochloride and Codeine Phosphate Oral Alternative, which include:

The believed qualifications risk of significant birth defects and miscarriage to the indicated populace is mysterious. All pregnancies Possess a qualifications hazard of start defect, decline, or other adverse outcomes.

Promethazine is greatly distributed in system tissues. Promethazine has significant protein binding with about 80 to ninety three% of promethazine bound to plasma proteins. Promethazine passes the blood brain barrier and also the placental barrier.

Actions of histamine on H1 receptors raises capillary permeability and edema development, flare and pruritus.

Promethazine HCl and codeine phosphate oral Answer, like other opioids, is often diverted for non-clinical use into illicit channels of distribution.

Promethazine HCl and codeine phosphate oral Alternative exposes patients and various buyers towards the pitfalls of opioid addiction, abuse, and misuse, which can result in overdose and Dying. Reserve promethazine HCl and codeine phosphate oral Option for use in Grownup individuals for whom the many benefits of cough suppression are predicted to outweigh the dangers, As well as in whom an enough assessment with the etiology in the cough continues to be made.

Parenteral drug abuse is commonly connected with transmission of infectious conditions such as hepatitis and HIV.

Steer clear of using promethazine HCl and codeine phosphate oral Option in patients taking muscle mass relaxants. If concomitant use is important, keep an eye on patients for signs of respiratory despair That could be higher than if not predicted.

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Opioids are sought by drug abusers and those with habit Ailments and therefore are subject to prison diversion. Look at these challenges when prescribing or dispensing promethazine HCl and codeine phosphate oral Resolution. Techniques to cut back these threats include things like prescribing the drug while in the smallest suitable quantity and advising the affected individual on the correct disposal of unused drug [see Affected person Counseling Information (17)].

Labor more info or Shipping and delivery Opioids cross the placenta and may produce respiratory melancholy and psycho-physiologic outcomes in neonates. An opioid antagonist, such as naloxone, have to be obtainable for reversal of opioid-induced respiratory despair in the neonate. Opioids, which includes promethazine HCl and codeine phosphate oral Answer, can prolong labor by means of actions which temporarily lessen the toughness, period, and frequency of uterine contractions.

Steer clear of the usage of promethazine HCl and codeine phosphate oral Resolution in adolescents 12 to 18 a long time of age who have other danger things which could maximize their sensitivity into the respiratory depressant consequences of codeine Until the benefits outweigh the challenges.

The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced, requiring very careful thought of the consequences within the mother or father drug, codeine, plus the active metabolite, morphine.